Intertrigo

What is intertrigo?

Intertrigo describes a rash in the flexures, such as behind the ears, in the folds of the neck, under the arms, under a protruding abdomen, in the groin, between the buttocks, in the finger webs, or in the toe spaces. Although intertrigo can affect only one skin fold, intertrigo commonly involves multiple sites. Intertrigo is a sign of inflammation or infection.

Who gets intertrigo?

Intertrigo can affect males or females of any age. Intertrigo is particularly common in people who are overweight or obese (see metabolic syndrome).

Other contributing factors are:

• Genetic tendency to skin disease
• Hyperhidrosis (excessive sweating)
• Age
• Diabetes
• Smoking
• Alcohol.

In infants, napkin dermatitis is a type of intertrigo that primarily occurs due to skin exposure to sweat, urine, and faeces in the diaper area.

Toe-web intertrigo is associated with closed-toe or tight-fitting shoes. Lymphoedema is also a cause for toe-web intertrigo.

What are the clinical features of intertrigo?

Intertrigo can be acute (recent onset), relapsing (recurrent), or chronic (present for more than six weeks). The exact appearance and behaviour depend on the underlying cause(s).

The skin affected by intertrigo is inflamed, reddened, and uncomfortable. The affected skin can become moist and macerated, leading to fissuring (cracks) and peeling.

Intertrigo with secondary bacterial infection (eg, pseudomonas) can cause a foul odour.

What causes intertrigo?

Intertrigo is due to genetic and environmental factors.

• Flexural skin has a relatively high surface temperature.
• Moisture from insensible water loss and sweating cannot evaporate due to occlusion.
• Friction from the movement of adjacent skin results in chafing.
• Intertrigo occurs more easily in environments that are hot and humid.
• Diabetes, alcohol, and smoking increase the likelihood of intertrigo, especially the infectious form.

The microbiome (microorganisms normally resident on the skin) on flexural skin includes Corynebacterium, other bacteria, and yeasts. Microbiome overgrowth in warm moist environments can cause intertrigo.

Intertrigo is classified into infectious and inflammatory origins, but they often overlap.

• Infections tend to be unilateral and asymmetrical.
• Atopic dermatitis is usually bilateral and symmetrical, affecting the flexures of the neck, knees and elbows.
• Other inflammatory disorders also tend to be symmetrical affecting the armpits, groins, under the breasts, and the abdominal folds.

Infections causing intertrigo

Thrush: Candida albicans

• Characterised by its rapid development
• Itchy, moist, peeling, red and white skin
• Small superficial papules and pustules

Intertrigo due to candida infection 

Erythrasma: Corynebacterium minutissimum

• Persistent brown patches
• Minimal scale
• Asymptomatic (painless and non-itchy)

Axillary erythrasma 

Tinea: Trichophyton rubrum + T. interdigitale

• Tinea cruris (groin) and athletes foot (between toes)
• Slowly spreads over weeks to months
• Irregular annular plaques
• Peeling, scaling

Tinea cruris 

Impetigo: Staphylococcus aureus and Streptococcus pyogenes

• Rapid development
• Moist blisters and crusts on a red base
• Contagious, so other family members may also be affected

Bullous impetigo 

Boils: Staphylococcus aureus

• Rapid development
• Very painful follicular papules and nodules
• Central pustule or abscess

Boil 

Folliculitis: Staphylococcus aureus

• Acute or chronic
• Superficial tender red papules
• Pustules centred on hair follicles
• Can be provoked by shaving, waxing, epilation.

Folliculitis in axilla 

Skin inflammations causing intertrigo

Flexural psoriasis

• Well-defined, smooth or shiny red patches
• Very persistent
• Common in submammary and groin creases
• Symmetrical involvement
• May fissure (crack) in the crease
• Red patches on other sites are scaly

Flexural psoriasis 

Seborrhoeic dermatitis

• Ill-defined salmon-pink thin patches
• Common in axilla and groin creases
• Fluctuates in severity
• May be asymmetrical
• Often unnoticed
• Red patches on the face and scalp tend to be flaky.

Intertrigo due to seborrhoeic dermatitis 

Atopic dermatitis

• First occurs in infancy
• Common in elbow and knee creases
• Characterised by flares
• Very itchy
• Acute eczema is red, blistered, swollen
• Chronic eczema is dry, thickened, lined (lichenified).

Flexural eczema 

Contact irritant dermatitis

• Acute, relapsing or chronic

Irritants include:

• Body fluids: sweat, urine
• Friction due to movement and clothing
• Dryness due to antiperspirant
• Soap
• Excessive washing.

Contact irritant dermatitis due to urine. Napkin dermatitis in adult 

Contact allergic dermatitis

• Acute or relapsing
• The allergen may be:
  • Fragrance, preservative or medicament in deodorant, wet-wipe or other product
  • Component of underwear (rubber in elastic, nickel in bra wire).

Intertrigo due to contact allergy to benzocaine 

Hidradenitis suppurativa

• Chronic disorder
• Boil-like follicular papules and nodules
• Discharging sinuses and scars

Intertrigo due to hidradenitis suppurativa in axilla 

Hailey-Hailey disease

• Intermittent painful shallow blisters that quickly break down
• Rare inherited condition
• Often starts age 20–40 years
• Most troublesome during summer months

Intertrigo due to Hailey-Hailey disease 

Granular parakeratosis

• Red-brown scaly rash
• Can be itchy
• Rare
• A biopsy is essential for diagnosis.

Granular parakeratosis 

Fox-Fordyce disease

• Dome-shaped follicular papules in armpits
• Often persistent
• Asymptomatic or itchy
• Reduced sweating
• Excoriations and lichenification eventually occur as a result of scratching.

Axillary Fox-Fordyce disease 

Toe-web intertrigo

• Common in persons wearing tight-fitting shoes
• Pseudomonas aeruginosa is the most common organism
• Mild toe-web intertrigo presents with erythema and scaling (athlete's foot)
• Chronic intertrigo (longer than six months) causes burning pain, exudation, maceration, and inability to move the toes
• A serious complication is cellulitis, often spreading to ankles and knees.

Athlete's foot 

What investigations should be done?

Investigations may be necessary to determine the cause of intertrigo.

• A swab for microscopy and culture of bacteria (microbiology)
• A scraping for microscopy and culture of fungi (mycology)
• A skin biopsy may be performed for histopathology if the skin condition is unusual or fails to respond to treatment.

What is the treatment for intertrigo?

• Treatment depends on the underlying cause if identified, and on which micro-organisms are present in the rash. Combinations are common.
• Zinc oxide paste can be used for napkin dermatitis or incontinence-associated irritant contact dermatitis.
• Physical exertion should be followed by bathing and completely drying skin flexures. A hairdryer on cool setting is an effective approach for drying underarms and breasts.
• Sweating can be reduced with an antiperspirant cream or powder.
• Bacterial infection may be treated with topical antibiotics such as fusidic acid cream, mupirocin ointment, or oral antibiotics such as flucloxacillin, cephalexin, and erythromycin.
• Yeasts and fungi may be treated with topical antifungals such as clotrimazole and terbinafine cream or oral antifungal agents such as itraconazole or terbinafine.
• Inflammatory skin diseases are often treated with low potency topical steroid creams such as hydrocortisone. More potent steroids are best avoided in the flexures because they can cause skin thinning, resulting in stretch marks (striae atrophicae) and rarely, ulcers. Calcineurin inhibitors such as tacrolimus ointment or pimecrolimus cream are also effective in skin folds.