What is infantile haemangioma?
Infantile haemangioma (American spelling ‘hemangioma’) describes a benign (non-cancerous) condition affecting cutaneous blood vessels. It is also known as proliferative haemangioma because it is due to proliferating endothelial cells; these are the cells that line blood vessels.
Infantile haemangiomas are proliferative lesions that usually develop shortly after birth. They are distinct from vascular malformations, which are usually present at birth and are less common.
Over 80% of infantile haemangiomas occur on the head and neck area. They grow to 80% of maximum size in the first three months and most stop growing at about 5 months. However, they may keep growing for up to 18 months.
After that, they undergo regression or involution. This can take as long as 3-10 years. Nearly all flat infantile haemangiomas eventually involute and disappear without treatment. However, regression of bulky haemangiomas tends to be incomplete, and they may leave an irregular atrophic (thin) scar or anetoderma (a dented scar) in at least 50% of cases.
Types of infantile haemangioma
Infantile haemangiomas are classified as superficial, deep or mixed lesions. They may be localised (confined to a small area) or segmental (involving a larger neuroectodermal unit).
- The superficial infantile haemangiomas is also called capillary haemangioma, capillary naevus, strawberry haemangioma, strawberry naevus, and haemangioma simplex. The blood vessels in uppermost layers of the skin are dilated.
- Deep infantile haemangiomas are also called cavernous haemangiomas and are more deeply set in the dermis and subcutis. They appear as a bluish soft to firm swelling.
- Both types of haemangiomas may occur together in mixed angiomatous naevi. A strawberry naevus overlies a bluish swelling.
Segmental haemangiomas are more serious than localised haemangiomas.
- They occur at a younger age and grow up to ten times larger
- They are consequently more unsightly
- Other congenital anomalies may be associated with facial segmental haemangiomas (PHACE syndrome). These includ posterior fossa abnormalities, haemangiomas, arterial abnormalities, cardiac abnormalities, and eye abnormalities.
- Likewise, segmental infantile haemangiomas involving the perineum may be associated with pelvic congenital anomolies, the PELVIS syndrome (perineal hemangioma with any of the following: external genital malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, or skin tag)
2 months of age
I year of age
2 years of age
The haemangiomas described below are all very rare conditons.
|Eruptive neonatal haemangiomatosis||
|Acquired multiple haemangiomatosis||
The Kasabach-Merritt syndrome is also known as haemangioma-thrombocytopenia syndrome. It is a rare complication of a rapidly growing vascular lesion, but is no longer thought to arise from ordinary infantile haemangiomas.
Which babies get haemangiomas?
Ten percent of babies develop one or more haemangiomas. Localised haemangiomas are more common if the baby has a low birthweight, for example in the following circumstances.
- White skin
- Multiple birth (twins)
- Advanced maternal age
- Family history of infantile haemangioma
Hypoxia (inadequate oxygen to the skin) is now considered the likely reason for the proliferation of blood vessels. Endothelial progenitor cells (EPCs) circulate in a fetus and cause new blood vessels to form in response to hypoxia. Normally, EPCs have gone by the time a baby is born, but they may still be present in low birthweight or premature babies. As the EPCs disappear later in life, the haemangioma may regress.
Segmental haemangiomas are thought to arise early in gestation (6-8 weeks) as a developmental error.
Investigations in babies with infantile haemangioma
Infantile haemangiomas are usually diagnosed clinically and no investigations are necessary for the majority of superficial lesions.
Deep infantile haemangiomas or segmental haemangiomas are routinely investigated with ultrasound scanning. An ultrasound scan is also often performed when there is uncertainty about the diagnosis or whether underlying tissues are affected. Characteristically, a haemangioma has a firm lobular structure with vessels separating the lobules.
It may also be necessary to perform Magnetic Resonance Imaging (MRI) or angiography to help plan treatment. Children with complex lesions are best assessed by a panel of experts, including paediatrician, dermatologist, radiologist, ophthalmologist, vascular and plastic surgeons.
Haemangiomas arising over the lower part of the spine are sometimes a marker for occult spinal dysraphism (spina bifida), when spinal imaging may be appropriate.
When is treatment necessary for infantile haemangioma?
Because infantile haemangiomas are likely to improve or regress completely with time, there is no need for specific treatment in most cases. Treatment should be considered in the following circumstances.
- Very large and unsightly lesions
- Ulcerating haemangiomas (up to 5-25% of lesions)
- Lesions that impair vision, hearing, breathing or feeding
- If they fail to resolve by school age
The baby is best assessed early i.e. during the rapidly growing phase under the age of 3 to 5 months of age. If the lesion obstructs vision, it may prevent the development of normal sight.
Propranolol is the treatment of choice for troublesome haemangiomas. Topical beta blockers such as timolol, available as eye drops or gel, can be used for for small superficial haemangiomas.
Other possible treatments include:
- External compression therapy (bandaging the limbs)
- Ultrapotent topical steroids
- Topical antiseptics. Eosin, which also has antiangiogenic properties, has been reported to be of benefit.
- Oral corticosteroids in high dose, during the proliferative stage of segmental disease (mostly superceded by propranolol)
- Sometimes, intralesional steroid injections have been used for small haemangiomas.
- Vascular laser therapy at age 3 to 4 years, when lesions are stable
- Interferon alpha may be useful but is rarely recommended, as it has been associated with the development of cerebral palsy in a few infants.
- Vincristine was reported effective in the past but is rarely used today
- Imiquimod has been reported to speed resolution in some cases.
- Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taïeb A. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008 Jun 12;358(24):2649-51. Medline.
- Keller RG, Patel KG. Evidence-Based Medicine in the Treatment of Infantile Hemangiomas. Facial Plast Surg Clin North Am. 2015 Aug;23(3):373-92. doi: 10.1016/j.fsc.2015.04.009. Review. PubMed PMID: 26208774.
- Hoeger PH, Harper JI, Baselga E, Bonnet D, Boon LM, Atti MC, El Hachem M, Oranje AP, Rubin AT, Weibel L, Léauté-Labrèze C. Treatment of infantile haemangiomas: recommendations of a European expert group. Eur J Pediatr. 2015 Jul;174(7):855-65. doi: 10.1007/s00431-015-2570-0. Epub 2015 May 29. Review. PubMed PMID: 26021855.
On DermNet NZ:
- Propranolol for infantile haemangiomas
- Differential diagnosis of vascular lesions
- Angiomas in adults
- Capillary vascular malformations
- Venous malformations
- Kasabach-Merritt syndrome
- PHACES syndrome
- PELVIS syndrome
- The Hemangioma and Vascular Birthmarks Foundation
- The National Organization of Vascular Anomalies
- Infantile Hemangioma –Medscape Reference
- Haemangioma of infancy – British Association of Dermatologists
- Hemangiomas: Patient Handouts – The Society for Pediatric Dermatology
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