Herpes viruses

Author: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand, 2013.

Synonyms:

Herpes virus group, Herpetoviridae, Herpes group virus, Family Herpesviridae, Alphaherpesvirinae, Betaherpesvirinae, Gammaherpesvirinae

Categories:

Viral infection

Subcategories:

Human herpesvirus 1, Herpes simplex virus 1, HSV1, Human herpesvirus 2, Herpes simpex virues 2, HSV2, Human herpesvirus 3, Varicella zoster virus, VZV, Human herpesvirus 4, Epstein Barr virus, EBV, Human herpesvirus 5, Cytomegalovirus, CMV, Human herpesvirus 6, Roseola infantum virus, Human herpesvirus 7, Human herpesvirus 8, Kaposi sarcoma-associated virus

ICD-10:

B00, B00.9, A70.00, B01, B02, B27.0, B25, B08.21, B08.22, C46.0

ICD-11:

1F00.00, 1E91.0,1E90.Z, 1D81.0, 1D82.Z, 1F01, 2B57.Z, 2B57.1

SNOMED CT:

128377001, 15302007, 467451003, 13687007, 407450002, 19551004,38907003, 40168006, 243579005, 28944009, 103528003, 442177008, 442002001, 402903007, 427605002, 713697009

The human herpes viruses (HHV) include several very common viruses that have cutaneous manifestations. The Herpesvirales family is characterised by:

Double-stranded DNA genome
Icosahedral capsid surrounded by a tegument
Lipid envelope derived from infected cell membranes modified by insertion of viral-encoded glycoproteins
Diameter of 160–200 nm
Infectious, latent (persistence in the host) and reactive phases of infection

The herpesvirus family
Subfamily	Genus	Species	Common name	Abbreviation	Condition
Alphaherpesvirinae	Simplexvirus	Human herpesvirus 1 (HHV1)	Herpes simplex virus 1	HSV1	Primary Herpes simplex (cold sores) Reactivation: Recurrent herpes, eczema herpeticum
	Simplexvirus	Human herpesvirus 2 (HHV2)	Herpes simplex virus 2	HSV2	Primary Genital herpes Reactivation: Recurrent herpes
	Varicellovirus	Human herpesvirus 3 (HHV3)	Varicella-zoster virus	VZV	Chickenpox Reactivation: Shingles
Betaherpesvirinae	Cytomegalovirus	Human herpesvirus 5 (HHV5)	Cytomegalovirus	CMV	Cytomegalovirus infection
	Roseolovirus	Human herpesvirus 6 (HHV6)	Roseola virus HHV6B		Roseola Reactivation: pityriasis rosea, drug hypersensitivity syndrome
	Roseolovirus	Human herpesvirus 7 (HHV7)	Roseola virus HHV6B
Gammaherpesvirinae	Lymphocriptovirus	Human herpesvirus 4 (HHV4)	Epstein-Barr virus	EBV	Infectious mononucelosis
Gammaherpesvirinae	Rhadinovirus	Human herpesvirus 8 (HHV8)	Kaposi sarcoma associated herpesvirus	KSV	Kaposi sarcoma

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Related information

References

Caselli E, Di Luca D. Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiologica 2007:30;173-187

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