Skin signs of systemic disease images

Carcinoma erysipeloides 

Angiofibromas in tuberous sclerosis 

Uraemic pruritus (renal itch) 

Angiofibromas in tuberous sclerosis 

SCC in situ 

Epidermolysis bullosa 

Venous eczema 

Thyroid goitre 

Epidermolysis bullosa 

Angiofibromas in tuberous sclerosis 

Café-au-lait macule 

Angiofibromas in tuberous sclerosis 

* 

Histology of cutaneous granuloma due to Crohn disease, New Zealand Medical Journal. 2006 

Actinic keratoses 

Eosinophilic granulomatosis with polyangiitis 

Pellagra dermatitis on forearms 

Systemic sclerosis 

Perifollicular haemorrhage and ecchymoses 

Lichen sclerosus 

Cutaneous mastocytosis 

Iron deficiency 

Periungual fibroma in tuberous sclerosis 

Recessive dystrophic epidermolysis bullosa 

Café-au-lait macule 

Angular cheilitis 

Focal dermal hypoplasia (Goltz syndrome) 

Oral Crohn disease 

Acrodermatitis enteropathica 

Angiofibromas in tuberous sclerosis 

Morgellon disease 

Purpura 

Morgellon disease 

Palmar pits 

Lichen planus 

Carcinoma erysipeloides 

Ash leaf marks in tuberous sclerosis 

Cystic BCC 

SCC in transplant patient 

Acute gout 

Acrodermatitis enteropathica 

Diabetic bullae 

Angiofibromas in tuberous sclerosis 

Contact dermatitis 

Periungual fibroma in tuberous sclerosis 

Venous eczema 

Thyroid ophthalmopathy 

Nodular melanoma 

Angiofibromas in tuberous sclerosis 

Nodular prurigo 

Lichen planus 

Ecchymoses 

Epidermolysis bullosa 

Ash leaf marks in tuberous sclerosis 

Shagreen patch in tuberous sclerosis 

Angiofibromas in tuberous sclerosis 

Lip cancer 

Insect bites 

Lip ulceration due to granulomatosis with polyangiitis 

Acrodermatitis enteropathica 

Epidermolysis bullosa 

Dry skin 

Acrodermatitis enteropathica 

Angiofibromas in tuberous sclerosis 

Porphyria cutanea tarda 

Superficial spreading melanoma 

Ash leaf marks in tuberous sclerosis 

Scratch marks 

Plexiform neurofibroma 

Superficial BCC 

Acral keratoses 

Rothmund-Thomson syndrome 

Thyroid ophthalmopathy 

Erythropoietic protoporphyria 

Contact dermatitis 

Hyperpigmentation 

Pompholyx 

Hypomelanosis of Ito 

Actinic keratoses 

Angiofibromas in tuberous sclerosis 

Superficial BCC 

Angiofibromas in tuberous sclerosis 

Lentigo maligna melanoma 

Epidermolysis bullosa 

Pretibial myxoedema 

Ulcerated mycosis fungoides, plaque stage 

Porphyria cutanea tarda 

Hypereosinophilic syndrome 

Angiofibromas in tuberous sclerosis 

Necrobiosis lipoidica 

Compulsive skin picking 

Lichen planus 

Ash leaf marks in tuberous sclerosis 

Ash leaf marks in tuberous sclerosis 

Urticaria 

Angiofibromas in tuberous sclerosis 

Epidermolysis bullosa 

Erythropoietic protoporphyria 

Porphyria cutanea tarda 

Multiple BCCs and scars 

Porphyria cutanea tarda 

Acrodermatitis enteropathica 

Hypereosinophilic syndrome 

IgG4-related disease: cutaneous inflammatory pseudotumour 

Angiofibromas in tuberous sclerosis 

Pathergy in Behcets 

Early poikiloderma 

Polycystic ovarian syndrome 

Abnormal thumb of younger sister 

Periungual fibroma in tuberous sclerosis 

Yellow plaques of PXE on the neck 

One month after treatment 

Compulsive skin picking 

Shagreen patch in tuberous sclerosis 

Carcinoma erysipeloides 

Seborrhoeic keratoses 

Café-au-lait macule 

Diabetic ulcer 

Normal palm colour and carotenoderma 

Osler node on ring finger as well as more subtle nodes seen on the little and middle finger 

Erythropoietic protoporphyria 

Acrodermatitis enteropathica 

Ehlers-Danlos syndrome 

Systemic sclerosis 

Gouty tophi 

Dermoscopy showing prominent telangiectasia in telangiectatic maculopapular cutaneous mastocytosis 

Bullous pemphigoid 

Porphyria cutanea tarda 

Erythropoietic protoporphyria 

Acrodermatitis enteropathica 

Angiofibromas in tuberous sclerosis 

Holocarboxylase synthetase deficiency 

Angiofibromas in tuberous sclerosis 

Gouty tophi 

Acrodermatitis enteropathica 

Angiofibromas in tuberous sclerosis 

Actinic keratoses 

Transient acantholytic dermatosis 

Acanthosis nigricans 

Contact dermatitis 

Insect bites 

Pretibial myxoedema 

Ash leaf marks in tuberous sclerosis 

Epidermolysis bullosa 

Periungual fibroma in tuberous sclerosis 

Acanthosis nigricans* 

Intramuscular, close-up 

Gouty tophi 

Holocarboxylase synthetase deficiency 

Nodules 

Episcleritis due to Crohn disease, New Zealand Medical Journal. 2006 

Costello syndrome 

Focal dermal hypoplasia (Goltz syndrome) 

Osler nodes on index finger. Note also the tiny splinter haemorrhages on fingernail also seen in end 

Angiofibromas in tuberous sclerosis 

Holocarboxylase synthetase deficiency 

Gouty tophi 

Xerosis 

Bullous pemphigoid 

Thyroid acropachy 

Angiofibromas in tuberous sclerosis 

* 

Epidermolysis bullosa 

Periungual fibroma in tuberous sclerosis 

Yellow plaques of PXE over the nape of the neck 

Focal dermal hypoplasia (Goltz syndrome) 

* 

Excoriations due to pruritus 

Variegate porphyria 

Acrodermatitis enteropathica 

Angiofibromas in tuberous sclerosis 

Variegate porphyria 

Acanthosis nigricans* 

Eczema craquelé 

Telangiectasia on back of hand 

Hypereosinophilic syndrome 

Hyperpigmented papules 

Periungual fibroma in tuberous sclerosis 

Morgellon disease 

Goitre 

LEOPARD syndrome 

Freckling in the armpit 

Gouty tophi 

Neurofibroma 

LEOPARD syndrome 

Tripe palms 

Angiofibromas in tuberous sclerosis 

Angiofibromas in tuberous sclerosis 

Shagreen patch in tuberous sclerosis 

Calcinosis cutis 

Angiofibromas in tuberous sclerosis 

Abnormal carrying angle 

Acanthosis nigricans 

Angiofibromas in tuberous sclerosis 

Insect bites 

Scarring 

Pigmentation on the buttock due to iron after intramuscular injection for iron deficiency 

Erythropoietic protoporphyria 

Necrolytic migratory erythema 

Cryopyrin-associated periodic syndrome rash 

Pompholyx 

IgG4-related disease: cutaneous inflammatory pseudotumour 

Ehlers-Danlos syndrome 

Orange-yellow palms of carotenoderma 

Granulomatous cheilitis due to Crohn disease 

Morgellon disease 

Psoriasis 

Angiofibromas in tuberous sclerosis 

Epidermolysis bullosa 

Angiofibromas in tuberous sclerosis 

Erythropoietic protoporphyria 

Erythropoietic protoporphyria 

Thyroid acropachy 

Erythropoietic protoporphyria 

Gouty tophi 

Close-up 

Angiofibromas in tuberous sclerosis 

Angiofibromas in tuberous sclerosis 

Hirsutism 

Polycystic ovaries 

Angiofibromas in tuberous sclerosis 

Angiofibromas in tuberous sclerosis 

Casal necklace 

Angiofibromas in tuberous sclerosis 

Cryopyrin-associated periodic syndrome rash 

Angiofibromas in tuberous sclerosis 

Periungual fibroma 

LEOPARD syndrome 

Compulsive skin picking 

Acrodermatitis enteropathica 

Angiofibromas in tuberous sclerosis 

Multiple BCCs and scars 

Acrokeratosis neoplastica 

Gouty tophi 

Morgellon disease 

Transparent skin 

Schnitzler syndrome 

Diabetic bullae 

Angiofibromas in tuberous sclerosis 

Necrolytic migratory erythema 

Thyroid ophthalmopathy 

Focal dermal hypoplasia (Goltz syndrome) 

Hereditary amyloidosis 

Neurofibroma 

Eosinophilic granulomatosis with polyangiitis 

Uraemic pruritus (renal itch) 

Recessive dystrophic epidermolysis bullosa 

Acrokeratosis neoplastica 

Rothmund-Thomson syndrome 

Facial papule 

Venous eczema 

Angiofibromas in tuberous sclerosis 

Before trichloroacetic acid treatment 

After trichloroacetic acid treatment 

Corkscrew hairs and purpura