Cytomegalovirus infection pathology

Figure 2

Histology of cytomegalovirus infection

Cytomegalovirus (CMV) is a member of the family Herpesviridae. In cutaneous cytomegalovirus infection, markedly enlarged endothelial cells are seen lining small vessels (Figure 1, arrows). These are larger and eosinophilic when compared with normal or reactive endothelial cells. The hallmark histologic feature is a large intranuclear inclusion which is densely eosinophilic (Figure 2, arrow). Other cells such as fibroblasts and epithelial cells are less commonly involved.

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