Mucin accumulation around the ankles causing nodules and plaques due to pretibial myxoedema (PTM-patient6)
Keywords: Bilateral lower leg, Infilitrative plaques, Infiltrative dermopathy, Leg, Localised myxoedema, Male, Mucin accumulation, Nodular pretibial myxoedema type, Pretibial, Skin-coloured nodules, Thyroid dermopathy
Pretibial myxoedema is a form of diffuse mucinosis in which there is an accumulation of excess glycosaminoglycans in the dermis and subcutis of the skin. Glycosaminoglycans, also called mucopolysaccharides, are complex carbohydrates that are important for tissue hydration and lubrication. The main glycosaminoglycan in pretibial myxoedema is hyaluronic acid, which is made by cells called fibroblasts.
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