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Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, January 2015.
Histopathological examination usually reveals a lobular panniculitis but septal involvement may be seen. In early stages, neutrophils are interstitially arranged between collagen bundles of the deep reticular dermis, followed by a neutrophilic mixed panniculitis with lobular necrosis (figures 1, 2, 3). Vasculitis has been described in association with significant neutrophilic infiltration.
Alpha-1-antitrypsin deficiency panniculitis pathology
Special stains and/or cultures for microorganisms can be helpful if an infectious aetiology is suspected.
Neutrophilic dermatoses: Clinical correlation can be needed to exclude other neutrophilic dermatoses. Usually patients are known to have alpha-1-antitrypsin deficiency when the panniculitis presents.
Factitial panniculitis: The sections should be polarised to exclude foreign material if a factitial cause is suspected.
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