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Hidradenoma papilliferum pathology

Author: Dr Harriet Cheng, Dermatology Registrar, Waikato Hospital, Hamilton, New Zealand; Dr Duncan Lamont, Pathologist, Waikato Hospital, Hamilton, New Zealand; A/Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.

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Hidradenoma papilliferum, also called papillary hidradenoma, is benign tumour arising from apocrine glands (see sweat gland lesions). The lesion is a small solitary dermal or subcutaneous nodule, most commonly on the vulva.

Histology of hidradenoma papilliferum

Hidradenoma papilliferum is a well-circumscribed dermal nodule, usually without connection to the overlying epidermis (figure 1). Tubules and broad, elongated fronds form an arborizing pattern and are lined with a double-layered epithelium (figures 2, 3). The inner layer is comprised of cuboidal myoepithelial cells and the outer is tall columnar apocrine cells with a pale eosinophilic cytoplasm, which may demonstrate decapitation secretion. Larger fronds may have a fibrous core. Fibrous tissue surrounding the tumour may be compressed to form a pseudocapsule.

Hidradenoma papilliferum pathology

Special studies of hidradenoma papilliferum

None are generally needed. Epithelial cells express keratin, EMA and CEA. GCDFP-15 (a marker of apocrine differentiation) is usually positive. Oestrogen, progesterone and androgen receptors may be positive. Myoepithelial cells express S-100 and smooth muscle actin. PAS positive granules are evident in the apices of apocrine cells.

Differential diagnosis of hidradenoma papilliferum

Syringocystadenoma papilliferum: Differentiating features of this crusted lesion include continuity of the lesion with surface epithelium and a prominent plasma cell infiltrate of the fibrous cores.

Malignant variant with intraductal carcinoma: Extensive infiltrative growth pattern with prominent mitotic activity and nuclear polymorphism.

Adenocarcinoma: Lacks a myoepithelial layer, shows marked nuclear atypia and an infiltrative growth pattern.



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  • Weedon’s Skin Pathology (Third edition, 2010). David Weedon
  • Pathology of the Skin (Fourth edition, 2012). McKee PH, J. Calonje JE, Granter SR

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