DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages
Home » Topics A–Z » Infantile digital fibromatosis pathology
Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
Infantile digital fibroma, also called inclusion body fibromatosis or Reye tumour, is a benign proliferation of myofibroblasts.
In infantile digital fibromatosis, sections show an intradermal unencapsulated tumour composed of spindle-shaped cells arranged in whorls or interdigitating sheets (figure 1). These myofibroblasts contain 3–10 μm inclusion bodies, which are round or ovoid and granular (figures 2-4, arrows are used to highlight some of the inclusion bodies in figure 2).
Earlier lesions of infantile digital fibromatosis are more inflammatory; more developed lesions display more fibroplasia and inclusion bodies.
The inclusion bodies stain pink with H&E (figures 2-4). The bodies are positive with immunohistochemical stains for actin and vimentin.
Fibromatosis – Identification of the characteristic inclusion bodies distinguish infantile digital fibromatosis from dermal fibromatosis and hypertrophic dermal scars
See smartphone apps to check your skin.
[Sponsored content]
See the DermNet NZ bookstore.
© 2021 DermNet New Zealand Trust.
DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice.