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Lichen planus pathology

Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2012.

Table of contents

Histology of lichen planus

Scanning power view of lichen planus shows a lichenoid reaction pattern (Figure 1) characterised by the combination of degeneration of the basal layer of the epidermis and a band like lymphocytic infiltrate obscuring the dermoepidermal junction. There is irregular epidermal hyperplasia forming a characteristic saw-tooth appearance with wedge-shaped hypergranulosis (Figures 1 and 2). The basal layer of the epidermis exhibits vacuolar degeneration with typically prominent necrosis of individual keratinocytes (Figure 3). The inflammatory infiltrate is chiefly lymphocytic and forms a dense band in the superficial dermis (Figure 4).

Lichen planus pathology

Special stains in lichen planus

On direct immunofluorescence in lichen planus, shaggy linear basement membrane and colloid body staining can be seen with fibrinogen.

Differential diagnosis of lichen planus

Lichenoid keratosis: The histologic findings of lichenoid keratosis (also called lichen planus-like keratosis) are largely not discriminatory, with distinction relying on the clinical setting. The presence of parakeratosis and an infiltrate containing increased numbers of eosinophils and neutrophils may distinguish this lesion from typical lichen planus. While an increased number of Langerhans cells are seen in lichen planus, an absolute number is not able to discriminate between these entities.

Keratosis lichenoides chronica: In addition to also containing numerous necrotic keratinocytes the epidermis of keratosis lichenoides chronical shows parakeratosis containing neutrophils. Clinical correlation is essential.



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