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Multinucleate cell angiohistiocytoma pathology

Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.

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Multinucleate cell angiohistiocytoma presents clinically as asymptomatic red-to-brown tumors, with a tendency to confluence.

Histology of multinucleate cell angiohistiocytoma

In multinucleate cell angiohistiocytoma, sections show abundant small dilated blood vessels and fibroplasia, principally in the mid-dermis (figure 1, 2). Higher power shows scattered bizarre cells (figures 3, 4) showing a pale basophilic cytoplasm and several nuclei arranged at the cell periphery (figure 3, arrow). A perivascular inflammatory infiltrate may also be seen.

Multinucleate cell angiohistiocytoma pathology

Special studies for multinucleate cell angiohistiocytoma

The multinucleate cells stain with vimentin and factor XIIIa. S100, CD34, and CD31 are negative.

Differential diagnosis of multinucleate cell angiohistiocytoma

Dermatofibroma – Some authors consider multinucleate cell angiohistiocytoma to be a variant of dermatofibroma. Dermatofibromas typically do not display the same degree of vascularity or the characteristic giant cells.



  • Pérez LP, Zulaica A, Rodríguez L. Multinucleate cell angiohistiocytoma. Report of five cases. J Cutan Pathol. 2006 May;33(5):349-52.

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