Lichen sclerosus pathology
Figure 4
Keywords: Histopathology-image, Lichen sclerosus, Pathology
Histology of lichen sclerosus
Scanning power of lichen sclerosus reveals a lichenoid inflammatory pattern in early stage lesions or a superficial sclerosing process in late stage lesions (Figure 1 and 2). The epidermis shows hyperkeratosis, significant thinning with loss of the normal rete ridge pattern and plugging of follicular infundibulae (Figure 3). An atrophic epidermis is not a requirement as some cases particularly in the vulva can show significant epidermal hyperplasia. Vacuolar degeneration of the basal layer can be seen though typically mild especially in late stage lesions. Clefting can be evident between the epidermis and dermis as a result of this basal layer degeneration and the underlying dermal changes. The dominant feature is of broad condensation of the dermal collagen. These changes are typically superficial, while in early lesions may show marked overlying papillary dermal oedema. When extending into the deep dermis discrimination from scleroderma may become difficult. The inflammatory infiltrate evolves from a dense lichenoid lymphocytic infiltrate to a sparse superficial interstitial infiltrate in late stage disease. Scattered plasma cells, histiocytes and mast cells can be seen (Figure 4).
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Source: dermnetnz.org