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Author: Brian Wu PhD. MD Candidate, Keck School of Medicine, Los Angeles, USA; Chief Editor: Hon A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand, February 2016.
Adams–Oliver syndrome is a rare condition characterised by various malformations of the limbs and abnormal skin development, particularly on the scalp.
Adams–Oliver syndrome is also known as:
Adams-Oliver syndrome is considered to be very rare, with an incidence of about 1 in 225,000 live births. The aetiology is unknown. However:
Adams–Oliver syndrome is caused by genetic mutations in at least 6 genes:
The primary features of Adams–Oliver syndrome include:
Diagnosis is based on clinical signs and symptoms, patient/family history, and imaging.
There is no cure for Adams–Oliver syndrome; treatment focuses in on symptom management and can include:
Long-term prognosis for Adams–Oliver syndrome is difficult to predict: it is not adequately described in medical literature due to a dearth of cases.
It should be noted that, in absence of major abnormalities, those with this condition should have a normal lifespan.
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