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Angioleiomyoma pathology

Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, December 2016.

Table of contents


Angioleiomyoma is an uncommon smooth muscle tumour arising from the smooth muscle of the vessel wall.

Histology of angioleiomyoma

Scanning magnification view of angioleiomyoma shows a circumscribed tumour nodule arising in the dermis or subcutaneous tissue (figure 1). The tumour is comprised of densely packed interlacing bundles of smooth muscle which surround small compressed vascular channels (figures 2, 3).

Angioleiomyoma pathology

Special studies

Immunostaining shows positive staining with muscle markers, Smooth muscle actin (SMA) and Desmin (figure 4 – SMA).

Angioleiomyoma – special stains

Differential diagnosis of angioleiomyoma

Myopericytoma: While this entity is also a circumscribed nodule which stains positively for muscle markers, it is comprised of perivascular concentrically arranged plump spindle to oval cells (glomoid-like) with eosinophilic cytoplasm.



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  • Pathology of the Skin (Fourth edition, 2012). McKee PH, J. Calonje JE, Granter SR
  • Hachisuga T, Hashimoto H, Enjoji M: Angioleiomyoma: A clinicopathologic reappraisal of 562 cases. Cancer 1984, 54:126-130 

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