Neurofollicular hamartoma pathology

Introduction

Neurofollicular hamartoma presents as a smooth flesh-coloured papule on the face.

Histology of neurofollicular hamartoma

In neurofollicular hamartoma, the histopathology shows a nodular dermal spindle cell proliferation surrounded by prominent sebaceous glands. The spindle cells are plump or wavy. The sebaceous proliferation surrounds the mesenchymal component (figures 1–3).

Figure 1

Figure 2

Figure 3

Special studies for neurofollicular hamartoma

The spindle cells are positive for S100, CD34 and Factor XIII. 

Differential diagnosis for elastofibroma

Other diagnoses to be considered include:

• Trichodiscoma — some authorities regard neurofollicular hamartoma to be a form of trichodiscoma.
  • S100 is usually negative in trichodiscoma
• Neurofibroma and neurotised naevus do not usually have malformed follicular and sebaceous structures.