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Neurofollicular hamartoma pathology

Author: Adjunct A/Prof Patrick Emanuel, Dermatopathologist, Clínica Ricardo Palma, Lima, Peru. DermNet NZ Editor in Chief: Adjunct A/Prof Amanda Oakley. October 2018. 

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Neurofollicular hamartoma presents as a smooth flesh-coloured papule on the face.

Histology of neurofollicular hamartoma

In neurofollicular hamartoma, the histopathology shows a nodular dermal spindle cell proliferation surrounded by prominent sebaceous glands. The spindle cells are plump or wavy. The sebaceous proliferation surrounds the mesenchymal component (figures 1–3).

Neurofollicular hamartoma pathology

Special studies for neurofollicular hamartoma

The spindle cells are positive for S100, CD34 and Factor XIII. 

Differential diagnosis for elastofibroma

Other diagnoses to be considered include:

  • Trichodiscoma — some authorities regard neurofollicular hamartoma to be a form of trichodiscoma.
    • S100 is usually negative in trichodiscoma
  • Neurofibroma and neurotised naevus do not usually have malformed follicular and sebaceous structures.   



  • Requena L, Yus ES, Simón P, del Rio E. Induction of cutaneous hyperplasias by
    altered stroma. Am J Dermatopathol. 1996 Jun;18(3):248–68. PubMed PMID: 8806959.

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