Home Topics A–Z Neurofollicular hamartoma pathology

Neurofollicular hamartoma pathology

Introduction

Neurofollicular hamartoma presents as a smooth flesh-coloured papule on the face.

Histology of neurofollicular hamartoma

In neurofollicular hamartoma, the histopathology shows a nodular dermal spindle cell proliferation surrounded by prominent sebaceous glands. The spindle cells are plump or wavy. The sebaceous proliferation surrounds the mesenchymal component (figures 1–3).

Neurofollicular hamartoma pathology

Figure 1

Figure 2

Figure 3

Special studies for neurofollicular hamartoma

The spindle cells are positive for S100, CD34 and Factor XIII. 

Differential diagnosis for elastofibroma

Other diagnoses to be considered include:

• Trichodiscoma — some authorities regard neurofollicular hamartoma to be a form of trichodiscoma.
  • S100 is usually negative in trichodiscoma
• Neurofibroma and neurotised naevus do not usually have malformed follicular and sebaceous structures.   

 

References

• Requena L, Yus ES, Simón P, del Rio E. Induction of cutaneous hyperplasias by
  altered stroma. Am J Dermatopathol. 1996 Jun;18(3):248–68. PubMed PMID: 8806959.

On DermNet NZ

• Dermatopathology glossary
• Dermatopathology index

Books about skin diseases

• Books about the skin
• Dermatology Made Easy book

 

Related information