Transient acantholytic dermatosis or Grover disease generally affects elderly men, who often present with pruritic erythematous papules, erosions and vesicles predominantly on the upper torso.
Histology of transient acantholytic dermatosis
There are four histological patterns described in transient acantholytic dermatosis. More than one histological pattern may be present.
- Darier-like pattern
- Hailey–Hailey-like pattern
- Pemphigus vulgaris-like pattern
- Spongiotic pattern
Microscopically, there is clefting in the upper layers secondary to acantholysis. There is usually a superficial dermal infiltrate of lymphocytes and eosinophils are sometimes present. Eosinophilic spongiosis is common in early lesions.
Transient acantholytic dermatosis pathology
Image provided by Dr Duncan Lamont, Waikato Hospital
Special studies in Grover disease
Direct immunofluroscence is negative.