DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages
Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2011.
Epidermolytic hyperkeratosis is a histological pattern seen in isolation or as an incidental finding in a number of dermatological conditions.
Low power view of histology of epidermolytic hyperkeratosis demonstrates hyperkeratosis and epidermal hyperplasia of varying degrees (Figure 1). The diagnostic features include a characteristic vacuolar degeneration with hypergranulosis of the stratum granulosum and stratum spinosum (Figures 2 and 3).
Epidermolytic acanthoma: When the changes of epidermolytic hyperkeratosis are seen forming a solitary lesion. Rarely multiple discrete lesions may be seen in disseminated epidermolytic acanthoma.
Bullous ichthyosiform erthyroderma: epidermolytic hyperkeratosis may be seen within biopsies of this generalised congenital condition.
Incidental: Epidermolytic hyperkeratosis may be seen in normal skin adjacent to any skin lesion or dermatosis.
Epidermolytic leukoplakia: is the term used for epidermolytic features arising on a mucosal surface (which is nonkeratinised).
Epidermal naevus variant: epidermolytic hyperkeratosis may be seen within some linear and systematised epidermal naevi.
See the DermNet NZ bookstore
© 2020 DermNet New Zealand Trust.
DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice.