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Glomeruloid haemangioma pathology

Author: Adjunct A/Prof Patrick Emanuel, Dermatopathologist, Clínica Ricardo Palma, Lima, Peru. DermNet NZ Editor in Chief: Adjunct A/Prof Amanda Oakley. September 2018. 

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Glomeruloid haemangioma is a rare benign cutaneous vascular proliferation that typically arises in patients with a history of POEMS syndrome.

Histology of glomeruloid haemangioma

In glomeruloid haemangioma, the histopathology shows numerous dermal ectatic vascular spaces lined by flat endothelial cells. Inside these dilated vascular spaces are a conglomeration of capillaries lined by plump, swollen endothelial cells, filled with red blood cells, resembling renal glomeruli (figures 1–4).

Glomeruloid haemangioma pathology

Special studies for glomeruloid haemangioma

None are generally needed.

Differential diagnosis for glomeruloid haemangioma

Other conditions that should be considered in the differential diagnosis for glomeruloid haemangioma include:

  • Angiosarcoma shows cytologic atypia and an infiltrative growth pattern
  • Intravascular papillary endothelial hyperplasia (Masson tumour) shows the formation of papillary structures lined by hyperplastic endothelial cells in the vascular lumen.



  • Lee JY, Choi JK, Ha JW, Park SE, Kim CW, Kim SS. Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome. Annals of Dermatology. 2017;29(2):249–51. doi:10.5021/ad.2017.29.2.249. PubMed Central

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