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Author: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand, 2002. Updated by Dr Jannet Gomez, October 2016.
Measles is a highly contagious viral infection causing fever and a rash. Early symptoms are like the common cold, with conjunctivitis (sore red eyes) and cough. Small white spots called Koplik spots may be seen in the mouth. A red blotchy rash appears on the face on the third day of the illness, spreads to the trunk, and becomes more generalised over the next few days.
Measles is also known as English measles, rubeola and morbilli. It is a notifiable disease.
Measles is caused by the measles virus, which belongs to the morbillivirus family.
Before widespread immunisation against measles in industrialised countries, measles was a very common childhood disease that carried a high death rate. Nowadays in countries where measles is part of an immunisation programme, the risk of exposure and incidence of actual disease cases is low. A recent trend by some parents not to immunise their children has led to an increase in the number of cases of measles, and its complications.
In developing countries, measles still occurs frequently and is associated with a high rate of complications and death. It remains a common disease even in some developed countries of Europe and Asia. Measles still causes more than a million childhood deaths each year.
Measles is highly contagious and is easily spread from person to person by breathing in airborne respiratory droplets from an infected person's coughing or sneezing.
An infected person is contagious from 2 days before any symptoms show to at least 5 days after the onset of rash.
An acute infection of measles almost always gives lifelong immunity.
Groups of individuals who are at greater risk of measles infection include:
Individuals at greater risk for severe measles and its complications include:
Measles appears as distinct clinical stages.
Diagnosis of measles is based on the characteristic history and physical examination. Because the disease is now so rarely seen in developed countries, any suspected cases require laboratory confirmation. This is particularly useful in the following situations:
The usual way to diagnose acute measles is using a viral nasopharyngeal swab and throat swab for polymerase chain reaction (PCR). Blood and urine samples can also be used. This should be done within 5 days of onset of rash, however, positive results are sometimes obtained up to 10–14 days after the rash has resolved.
Blood is also taken for measles IgM and IgG antibodies (serology). Levels of IgM become elevated during the active infection phase and IgG antibody appears during the recovery phase.
Viral culture of the throat and nasopharyngeal swabs is preferred in immunocompromised patients where serological evidence might be absent due to decreased immune response. An immunofluorescence test for measles antigen can also be considered in patients with poor immunity.
There is no specific treatment for measles, which is why immunisation is so important. Treatment for mild cases of measles is supportive. Bed rest is vital, as it prevents complications and prevents the spread of the virus.
Patients with drowsiness, dehydration, or discomfort breathing require hospitalisation for supportive care.
Antibiotics are needed to treat secondary bacterial infections from complications such as otitis media, infectious diarrhoea, pneumonia and sepsis. Ribavirin (antiviral) is used to treat measles infection in immunocompromised patients and in those affected with subacute sclerosing panencephalitis.
Approximately 30% of reported measles cases have one or more complications.
Rarely, subacute sclerosing panencephalitis—a fatal condition—develops decades after a measles infection due to persistence of the measles virus in the central nervous system.
Measles can be prevented by vaccination with live attenuated measles vaccine. It is available as a single antigen preparation or combined with live attenuated mumps or rubella vaccines, or both. Combined measles, mumps and rubella (MMR) vaccine is currently part of routine immunisation programmes in most industrialised countries, including New Zealand.
Measles vaccine induces long-term (probably life-long) immunity in most individuals. Vaccination schedules recommend a two-dose immunisation strategy, the first dose at 12–15 months, followed by a second dose at 4–6 years.
Measles vaccine should not be given during pregnancy. Women not previously immunised against measles should avoid pregnancy for one month (28 days) after receiving the MMR vaccine.
Immune globulin does not prevent measles, but it is helpful in decreasing the severity of illness in those exposed to the virus. It is recommended for:
Individuals vaccinated prior to 1968 may require revaccination, as vaccines used before this time may not have conferred life-long immunity.
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