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Triggers for Stevens–Johnson syndrome / toxic epidermal necrolysis

Medicines (listed alphabetically)

This list of drugs known to cause SJS/TEN is not exclusive.

• Abacavir
• Acetominophen
• Allopurinol
• Antibiotics
• Anticonvulsants
• Antifungals
• Antivirals
• Atenolol
• Azathioprine
• Beta-lactam antibiotics
• Captopril
• Carbamazepine
• Cephalosporins
• Clomipramine
• Dapsone
• Diltiazem
• Gold salts
• Ibuprofen
• Imidazole antifungals, eg ketoconazole, itraconazole, fluconazole
• Isoniazid
• Lamotrigine
• Mexiletine
• Minocycline
• Naproxen
• Nevirapine (non-nucleoside reverse-transcriptase inhibitor)
• Nonsteroidal anti-inflammatory drugs (NSAIDs)(oxicam type mainly)
• Paracetamol
• Penicillins
• Phenobarbitone
• Phenytoin
• Sulfasalazine
• Sulfonamides
• Trimethoprim
• Valproic acid
• Vemurafenib

Other causes

• Mycoplasma pneumoniae and cytomegalovirus infections
• Vaccinations
• Cancer, especially haematological cancers
• Systemic diseases
• Contrast medium
• External chemical exposure
• Herbal medicines
• Foods
• Bone marrow transplantation
• Radiotherapy

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