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Skin grafting

Last reviewed: August 2023

Author(s): Dr Jamie Banks, Department of Plastic and Reconstructive Surgery, St George’s University Hospitals, U.K. (2023)
Previous contributors: Dr Sonya Havill, Dermatologist, New Zealand (2002)

Reviewing dermatologist: Dr Ian Coulson

Edited by the DermNet content department


What is a skin graft?

A skin graft consists of skin taken from one part of the body to cover an area where skin is missing or damaged. This may follow surgical removal of skin cancer or an injury such as a burn or other trauma.

Unlike ‘flap’ reconstruction which has its own intrinsic blood supply, a skin graft is a free piece of tissue which receives blood supply from the bed onto which it is grafted and therefore its survival relies on the integrity of the underlying wound bed.

Why do you need a skin graft?

A skin graft is required when the area of skin loss is too big to be closed using local skin and stitches alone. While with very superficial wounds, the cells that create the new top layer of skin remain intact, in deeper wounds (such as full-thickness excisions of skin cancers), this layer is lost and the surgeon may need to kickstart the healing process with a graft of healthy skin cells from elsewhere. 

The skin graft covers the wound, attaching itself to the cells beneath, and begins to grow in its new location. Similarly, a skin graft may be used after removal of a skin cancer if the dermatologist or surgeon is worried that they may need to return to take a further margin of tissue to ensure clearance. If a skin graft wasn’t performed, the area would be an open wound and take much longer to heal.

What are the types of skin grafts?

Split-thickness skin grafts

Split-thickness skin grafts (STSG) are also known as split skin grafts (SSG) or partial-thickness skin grafts.

This type of graft is taken by shaving a very thin surface layer (epidermis and a variable thickness of dermis) of the skin with a special machine called a dermatome, or manually with a large knife. The machine is powered by air and quite noisy. The shaved piece of skin is then applied to the wound.

  • STSGs are often taken from the thigh, but if larger areas are required (as with burn surgery), other areas can be utilised.
  • A split skin graft is often used after excision of a lesion on the lower leg or scalp.

STSGs may then be meshed to increase the area they can cover and their ability to contour to the defect. The donor site heals on its own with dressings over a few weeks.

Full-thickness skin grafts

A full-thickness skin graft (FTSG) is taken by removing all the layers of the skin down to the fat with a scalpel. It is done in a similar way to skin excision. The piece of skin is cut into the correct shape, then applied to the wound. 

  • This type of graft is often taken from the inner upper arm, neck, or in front of or behind the ear, where there is more laxity in the skin to facilitate closure of the donor site.
  • It is often used after excisions on the hand or face.

Since it includes the full layer of dermis, it has a better cosmetic outcome than a split-thickness graft, less contraction (shrinkage) over time, and more resistance to subsequent trauma. However, due to the increased thickness, FTSGs initially have a lower chance of graft survival. They are also limited by the size of the donor site, as harvesting leaves a full-thickness defect that must itself be managed and stitched closed.

Composite grafts

Composite grafts are a specialist type of graft used in some unique situations. They include all the skin layers, as well as some of the underlying fat, and can include underlying cartilage from the donor site. They can be used to reconstruct fingertips following traumatic amputation (using the amputated part to provide the graft) or to reconstruct special areas like the nasal tip after removal of skin cancers. Broadly speaking, their post-operative management is similar to full-thickness skin grafts.

Cadaveric grafts

The above examples describe autografts, where the graft is taken from the person who will receive it. Cadaveric grafts are an allograft, where the graft is taken from an organ donor. These, along with xenografts (taken from a different species such as porcine/pig grafts), can trigger the recipient’s immune system to reject the tissue over time. As such, they are preserved for use in acute trauma, typically following massive burns, as a temporising measure until sufficient autograft can be sourced.

Taking this a step further, cadaveric grafts can also be used as a dressing on top of an autograft to improve the chance of the underlying autograft succeeding in very unwell patients, in a novel process known as sandwich grafting.

Skin substitutes

A range of skin substitutes are also available for reconstruction instead of, or in combination with, skin grafts:

CEA (cultured epidermal autograft):

A sample of skin tissue is taken and grown in the lab over a three-week period into a new epidermis, before being applied in a manner similar to a thin split-thickness graft. Unsurprisingly, these very thin grafts are very susceptible to damage and often require longer immobilisation to prevent shear forces and graft loss. They are expensive and require a growth phase before use.

ASCS (autologous skin cell suspension):

This uses a similar technique to CEA, but applies the newly grown cells as a spray rather than as a preformed graft.

Dermal substitutes:

This is used to reconstruct the dermis, serving as temporary or permanent scaffolds that promote wound healing and facilitate the regeneration of new tissue. They can be synthetic or biological, with the latter’s collagen derived from human or animal sources. This is gradually replaced by the recipient’s own collagen to support a subsequent skin graft.

These substitutes can be applied over areas that would not usually form an adequate wound bed to receive a graft, such as exposed bone or tendon. This allows for a subsequent split-thickness graft to be applied as a second stage. As with CEA and ASCS, the cost of dermal substitutes limits their use.

What is involved in having a skin graft?

Before the procedure 

Your doctor will explain to you why a skin graft is required, and the process involved. You may have to sign a consent form to indicate that you understand and agree to the surgical procedure.

Tell your doctor:

  • If you are taking any medication (particularly blood thinners such as aspirin, clopidogrel, ticagrelor, dabigatran, rivaroxaban, apixaban, or warfarin)
  • If you have any allergies, medical conditions, or a pacemaker or implanted defibrillator
  • About any over-the-counter supplements and herbal remedies (as these can also lead to abnormal bleeding).

During the procedure

If the graft is used to cover an area resected due to skin cancer, your surgeon will measure the area of the wound to know what size to make the skin graft. A piece of skin will be shaved or cut from another part of your body (donor site) that is large enough to cover the wound. When possible, skin of similar thickness and colour will be selected. Occasionally, your surgeon may conduct the operation in stages using a tissue expander. This is a device that works like a balloon under the skin to stretch the area and increase the amount of skin that can be subsequently harvested in a graft.

Once harvested, a split-thickness skin graft may be meshed, where the graft is turned from a continuous sheet into a mesh that looks like a fishing net. This allows a smaller donor site to cover a larger area, improves the contouring to underlying graft bed (which increases the chance of the graft succeeding), and prevents build-up of fluid under the graft. When the dressing is first removed, the graft will look like a criss-cross pattern, but the holes will fill in with time to appear similar to the surrounding skin. Grafts may also be ‘fenestrated’ where small holes are cut to reduce the risk of blood building up underneath the graft, but traditionally fenestration does not increase the area that a graft can cover.

The piece of skin (the graft) will be applied to the wound and is usually secured in place with stitches or surgical staples. A special spongy dressing will be applied directly over the skin graft and often sutured in place. An outer pressure dressing will then be applied to protect the wound. Sometimes a vacuum dressing (known as topical negative pressure therapy) is used for large grafts.

After the procedure

You will have two wounds, the site of the original lesion and the donor site. They may become tender after an hour or two when the effect of the local anaesthetic wears off.

Skin grafts are very fragile and great care must be taken when looking after them.

  • Leave the dressing in place as advised (usually for ~7 days until you see the doctor or nurse again). Make sure you have instructions on how to care for the wound and when to get the stitches out.
  • Limit movement of the area for 2–3 days to allow time for the graft to adhere and develop a blood supply from the wound bed.
  • Avoid strenuous exertion or stretching of the area until the stitches are removed and for some time afterwards.
  • If there is bleeding, press on the wound firmly with a folded towel for 20 minutes (without removing the original dressing). If still bleeding after this time, seek medical attention.
  • Do not rub the area, as this may disturb the graft.
  • Keep the wounds clean and dry until your surgeon advises that you can wash them.
  • If you have had a split-thickness skin graft, the donor site will usually be checked after 10–14 days to make sure it is healing properly.
  • If the wounds become red or very painful, consult your doctor: they could be infected.

Split-thickness graft donor sites take about two weeks to heal, whereas full-thickness graft donor sites typically heal a little faster, between 5–7 days. The graft itself ought to develop its new blood supply in 5–7 days; it can take as long as 1–2 years until the area fully settles.

What are the complications of skin grafts?

General risks

  • Pain — in split-thickness grafts, this is usually worse in the donor site as the cutaneous (skin) nerves are exposed in harvesting. It typically improves as the site heals and is manageable with simple analgesia (painkillers).
  • Infection — of the graft where it is applied (increasing the chance of failure) or in the donor site.
  • Bleeding — increased risk if you are taking blood thinners. It is usually controlled in the operation, but sometimes ongoing oozing can lead to a haematoma (collection of blood) that stops the skin graft from adhering (sticking) to the wound bed; this will lead it to fail.
  • Scarring — this is discussed more below and is inevitable to some degree with any operation that cuts through the skin.
    • Some people’s bodies try to heal too vigorously, and the new tissue can cause an overgrowth called overgranulation. If this happens, your doctor will be able to advise on treatments to dampen down this overgrowth.
    • Particularly in split-thickness grafts, the graft may contract slightly as it heals. This can lead to tightness over time, especially if applied over joint creases, known as a contracture and may require a further procedure to correct.

Specific risks for skin grafts

  • Failure of the graft — this can be complete failure or failure of a portion of the graft. It is explored in more detail below.
  • Delayed wound healing – if the graft fails, is complicated by infection, or is grafted onto tissue that is already compromised (such as in peripheral vascular disease or diabetic patients), the wound can take longer than expected to heal and may require long-term dressings.
  • Donor site morbidity — the risks of poor healing described for the graft site also apply to where the graft was taken from.
  • Cosmesis — skin grafts may not have a perfect colour or contour match to the surrounding skin.

Graft failure

Sometimes the skin graft does not survive the transfer to the new site. This usually happens within the first two weeks after the procedure. It can happen for a variety of reasons including the accumulation of blood or fluid underneath the graft, and/or wound infection.

If this happens, a repeat skin graft procedure may be suggested, or the wound may be dressed regularly and left to slowly heal on its own. It is quite normal for the graft to appear dark, bruised, and crusted on the surface when the dressings are removed early on. This does not necessarily mean it has failed.

In some instances, your doctor may advise against a skin graft at all and opt for prolonged dressings until the wound heals. These situations can include chronic wounds which would be a poor recipient site for a skin graft, scarred or irradiated areas (after radiotherapy), and joints or areas with high mobility where the graft would almost certainly shear and fail.


It is impossible to cut the skin without scarring to some degree. The final cosmetic result depends on the type of skin graft, the location, the size and depth of the wound, and patient factors. Because skin grafts are effectively a patch without their own blood supply and sometimes of less thickness than the wound they are applied to, the final appearance may not be as close to normal as it would be if the wound was able to be closed in a straight line or with a skin flap. The grafted area may look paler and flatter than the surrounding skin with time.

You will have two scars: the scar where the skin graft has been applied, and the donor site. The donor site for a full-thickness skin graft will usually be closed in a straight line with stitches. The donor site for a split-thickness graft will consist of a superficial graze and will heal itself more slowly (initially under a special dressing).

Some people have an abnormal response to skin healing resulting in larger scars than usual (keloid or hypertrophic scarring).



  • Bright A, Leonard C, Lindsey L, et al. The Sandwich Technique: Cadaveric Allograft Overlay to Protect Posterior Truncal Split Thickness Skin Grafts. Journal of Burn Care & Research. 2018;39(suppl 1):S134. doi 10.1093/jbcr/iry006.251. Journal
  • Elseth A, Nunez Lopez O. Wound Grafts. In: StatPearls. Treasure Island (FL); StatPearls Publishing; October 31, 2022. Available here
  • Petrie K, Cox CT, Becker BC, MacKay BJ. Clinical applications of acellular dermal matrices: A review. Scars Burn Heal. 2022;8. doi: 10.1177/20595131211038313. Journal

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