Introduction Clinical features Dermoscopic features Differential diagnoses Histological explanation
Cutaneous squamous cell carcinoma is a common type of keratinocytic or nonmelanoma skin cancer. It is commonly found on sun-exposed areas of skin. It can be invasive and metastasise. It is also known as cutaneous squamous cell carcinoma, and commonly abbreviated to SCC.
Cutaneous squamous cell carcinoma presents clinically as an enlarging, irregular, keratinous nodule or a firm erythematous plaque that frequently ulcerates.
They usually arise within pre-existing actinic keratosis or intraepidermal carcinoma.
The common dermoscopic features of cutaneous squamous cell carcinoma are:
Pigmented cutaneous squamous cell carcinoma has brown, blue or grey areas.
The dermoscopic differential diagnosis of cutaneous squamous cell carcinoma includes its variants:
Other conditions to consider include:
Histologically, there is a proliferation of atypical keratinocytes within the dermis.
