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Angina bullosa haemorrhagica

Author: Dr Mark Duffill, Hamilton, New Zealand, 2008

Table of contents

What is angina bullosa haemorrhagica?

Angina (painful), bullosa (a blister), haemorrhagica (blood-filled, American spelling hemorrhagica) describes a condition where an, often painful, tense, blood-filled blister or blisters develop in the mouth.

Angina bullosa haemorrhagica

What are the symptoms of angina bullosa haemorrhagica?

The soft palate is the most common site. Other sites inside the mouth may be involved. There is usually a solitary lesion. Multiple blisters may develop. The blisters usually rupture spontaneously and the sites heal uneventfully

What is the cause of angina bullosa haemorrhagica?

Possible causative factors include trauma, long-term use of topical or inhaled steroids, diabetes and hereditary predilection.

Other conditions which may need consideration include mucous membrane pemphigoid, bullous pemphigoid, lichen planus, epidermolysis bullosa, dermatitis herpetiformis, linear IgA disease and oral amyloidosis.


None are usually needed unless the above conditions need to be excluded. Skin antibodies may be measured. If a biopsy is taken in angina bullosa haemorrhagica, a blister will be found under the mucosa (lining of the mouth). This contains red blood cells and sparse inflammatory cells.


No treatment is usually necessary other than a mild analgesic and/or a simple mouth wash.



  1. Yip HK. Angina bullosa haemorrhagica: a case report and a concise review. Gen Dent. 2004 Mar-Apr;52(2):162–4. Medline.
  2. Giuliani M, Favia GF, Lajolo C, Miani CM. Angina bullosa haemorrhagica: presentation of eight new cases and a review of the literature. Oral Dis. 2002 Jan;8(1):54–8. Medline.

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