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Pruritic papular eruption of HIV

Author: Ben Tallon, Dermatology Registrar, Auckland Greenlane Hospital, 2007.

Pruritic papular eruption of HIV — codes and concepts

What is pruritic papular eruption of HIV?

Pruritic papular eruption of HIV (Human Immunodeficiency Virus) is often reported as the most common rash seen in HIV infection. It is a form of prurigo. Anywhere between 18 and 46% of patients with HIV have this condition at some time. It can be very distressing for patients as it can be disfiguring and stigmatising. Often treatment is disappointing.

What causes pruritic papular eruption of HIV?

Strictly this rash is a diagnosis of exclusion, when all other causes have been ruled out. This means that currently there is no identified cause. Arthropod bites, medications, autoimmunity and direct HIV infection of the skin have all been considered, but not proven.

Unfortunately many reports in the literature include a number of other conditions under the heading of pruritic papular eruption of HIV. These include

It is necessary to consider and exclude these other conditions before a diagnosis is made. In most cases a skin biopsy is required.

What are the signs and symptoms?

Pruritic papular eruption of HIV is nearly always a very itchy rash. It presents as multiple discrete scratched red bumps, which are symmetrical and diffusely distributed. The extremities and trunk are affected more than the face. The mucous membranes (mouth, nostrils, eyes, genitals), palms, and web spaces are spared.

It is the presenting symptom of HIV in 25-79% of cases. It is also a skin sign of advanced HIV, being three times more common when the CD4 lymphocyte count is less than 200 x109/L.

What treatments are available?

Unfortunately pruritic papular eruption of HIV often proves very resistant to treatment. However, there are a number of different treatment approaches that have been shown to be effective in at least some patients.

Topical steroid, emollients and oral antihistamines should be the first line approach, because of their availability and safety.

Failing this phototherapy (UVB or PUVA) should be commenced. This is usually effective. The average time for the skin condition to recur is 8 weeks.

Another reported useful agent is oxpentifylline. This is thought to be work by its TNFα inhibitor effect. The usual dose is 400mg three times daily for at least 8 weeks.

Whether HAART (Highly Active Anti-Retroviral Therapy) makes a difference is debated and the response is variable. But because some people have seen consistent responses, there has been a recommendation that pruritic papular eruption is used as qualification for initiating HAART.

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Related information



  • Efficacy of pentoxifylline in the treatment of pruritic papular eruption of HIV-infected persons. J Am Acad Dermatol. 1998 Jun
  • Papular follicular eruptions in human immunodeficiency virus-positive patients in South Africa.
  • Int J Dermatol. 2007 Jul;46(7):706-10. Budavari JM, Grayson W.
  • Spectrum of skin disorders in human immunodeficiency virus-infected patients in Singapore and the relationship to CD4 lymphocyte counts. Int J Dermatol. 2007 Jul;46(7):695-9.
  • Cutaneous manifestations of HIV in the era of highly active antiretroviral therapy: an institutional urban clinic experience. Zancanaro PC et al. J Am Acad Dermatol. 2006 Apr;54(4):581-8.

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