DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages
Author: Vanessa Ngan, Staff Writer, 2005. Updated by Dr Ebtisam Elghblawi, Dermatologist, Tripoli, Libya, and DermNet NZ Editor in Chief, A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand, November 2017.
Atypical fibroxanthoma (AFX) is a dermal spindle-cell tumour that typically occurs on the head and neck of sun damaged older people. The tumour-like growth should be considered a type of skin cancer but it may behave in a benign fashion.
A rare type of atypical fibroxanthoma occurs in younger patients on parts of the body that are not normally overexposed to the sun. These tumours are usually found on the trunk and extremities and tend to be larger and slower growing.
The development of atypical fibroxanthomas is associated with ageing, sun exposure (ultraviolet radiation) and/or ionising radiation (X-rays). Both forms of radiation can cause abnormal growth of atypical spindle cells. These are believed to come from fibrous cells in the dermis or from epidermal keratinocytes.
Reports have shown an increased incidence of atypical fibroxanthoma in patients with acquired immune deficiency syndrome (AIDS) and in patients who are immune suppressed, for example because of organ transplantation.
Atypical fibroxanthoma affects both sexes equally, with a mean age of 69 years at diagnosis.
Atypical fibroxanthoma often appears in areas that have received excessive sun exposure, usually around the scalp, ears, nose, cheeks, and back of the neck, or in areas where individuals may have previously received radiotherapy treatment. They have also been reported to occur on the trunk, extremities, and in sun-protected areas.
Although rare, cutaneous metastases from atypical fibroxanthoma have been reported.
Because atypical fibroxanthoma can look like other skin cancers, it is usually diagnosed by a pathologist after a skin biopsy or excision.
The diagnosis depends on finding large, pleomorphic, fibrocytic, spindle-shaped, anaplastic tumour cells haphazardly arranged in the dermis. Immunohistochemistry stains should be undertaken but may be nonspecific. Cytokeratin and melanoma stains are negative.
Atypical fibroxanthoma macro + dermoscopy
Other lesions to be considered in the differential include:
Atypical fibroxanthoma is treated by complete surgical excision. Small lesions may be removed by curettage. Mohs micrographic surgery is becoming the treatment of choice for large or recurrent lesions, as it reliably removes the complete tumour while sparing surrounding normal healthy tissue.
Atypical fibroxanthoma rarely recurs after complete excision with clear margins. Recurrence and metastasis are more likely in people that are immunosuppressed.
Most cases of atypical fibroxanthoma could be prevented by avoiding excessive sun exposure. Patients are advised to follow sun protection methods when outdoors.
© 2020 DermNet New Zealand Trust.
DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice.