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Author: Dr Delwyn Dyall-Smith FACD, Dermatologist, 2010.
Cheilitis means inflamed lips. There are various causes.
Exfoliative cheilitis is a rare reactive condition presenting as continuous peeling of the lips.
Factitial cheilitis can present as exfoliative cheilitis, when it is due to attention-seeking or factitial behaviour or an obsessive-compulsive tendency to pick or chap the lips (exfoliative).
Exfoliative cheilitis is rarely reported but appears to affect both sexes equally and mainly affects young adults less than 30 years of age.
Some patients diagnosed with exfoliative cheilitis actually have a localised form of psoriasis.
Factitial cheilitis may be triggered by a stressful event leading to an element of self-damaging behaviour.
Whatever the underlying cause, exfoliative cheilitis can be made worse by:
Poor oral hygiene has also been reported in association with exfoliative cheilitis and considered to be a possible predisposing trigger. One form of the condition is associated with HIV infection.
Whatever the cause, excessive keratin formation results in the abnormal peeling.
Exfoliative cheilitis presents with continuous peeling of the vermilion (outer) part of the lips. It may affect just one lip, usually the lower. The lip may look normal or red before the formation of the thickened surface layer. The peeling appears to be cyclical and proceeds at different rates in different sites, so there is always some part of the lip peeling at any time. There may be associated bleeding resulting in formation of a haemorrhagic crust. When both lips are involved, the lower lip is usually more affected than the upper.
The condition may be painful, causing difficulty in eating and speaking. Other symptoms reported include sensations of:
Ulceration or fissuring may occur.
Depression and personality disorders have been reported commonly in association with factitial exfoliative cheilitis. However the cheilitis itself can be of such unpleasant appearance that the patient avoids social situations, contributing to mood disturbance.
The typical course of exfoliative cheilitis is chronic over years. It may fluctuate, worsening with further stress. Spontaneous improvement has been reported, but it often recurs.
As exfoliative cheilitis can look similar to other conditions, tests are required to exclude these other conditions and secondary infection.
Exfoliative cheilitis is a diagnosis of exclusion and there is no specific diagnostic test for it. A careful psychiatric assessment can be especially helpful as treatment of an associated mood or anxiety disorder has been reported to also improve factitial exfoliative cheilitis.
Infection should be treated topically or systemically, if present.
Unless a predisposing or associated condition can be identified and treated, exfoliative cheilitis is typically resistant to treatment. Unsuccessful use of keratolytic lip balms, sunscreen, antifungal creams, topical steroids, systemic steroids, antibiotics, vitamin D analogues (calcipotriol) and cryotherapy have been described. There has been one report each of the successful use of topical tacrolimus and Calendula officinalis (marigold) ointment 10%.
Treatment of an associated mood or anxiety disorder has been reported to improve factitial cheilitis. Obsessive-compulsive disorders respond best to selective-serotonin-reuptake inhibitors.
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