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Naevus of Ota, naevus of Ito and naevus of Hori

Author: Vanessa Ngan, Staff Writer, 2003.


What is a naevus?

A naevus (American spelling nevus, nevi) is a circumscribed and stable malformation of a component of the skin. Naevi (American spelling nevi) are often present at birth, when they are often called brown birthmarks. Naevi composed of melanocytes (the pigment cells that produce melanin) are called melanocytic naevi or pigmented naevi.

What are Ota, Ito and Hori naevi?

Naevus of Ota, naevus of Ito and naevus of Hori are special melanocytic naevi that have a slate-brown or blue/grey colouring. They are forms of dermal melanocytosis  in which naevus cells are found deep within the dermis.

  • Naevus of Ota is on the forehead and face around the eye area. Hyperpigmentation of parts of the eye may occur (sclera, cornea, iris, retina)
  • Naevus of Hori is similar to naevus of Ota but affects both sides of the face
  • Naevus of Ito is on the shoulder and upper arm area (shoulder girdle).

Dermal melanocytosis can also occur elsewhere on the body, including inside the mouth.

Naevus of Ota
Naevus of Ito

How does dermal melanocytosis arise, and who is at risk?

It is not known why dermal melanocytosis occurs. Specific mutations have been detected within the dermal melanocytes, most often GNAQ or GNA11. Researchers have suggested that hormones play a part in their development. The role of ultraviolet radiation is thought to be small, as it does not reach deep dermal melanocytes.

Naevus of Ota is much more common than naevus of Ito. These naevi are present at birth in 50% of cases but may appear during adolescence or adult life. Naevus of Hori is not present at birth and is therefore a form of acquired melanocytosis.

Naevi of Ota and Ito are most commonly found in Asian populations; 0.2–0.6% of Japanese people have a naevus of Ota. They appear more frequently in females. Both forms of naevi are uncommon in Caucasians.

What are the signs, symptoms and complications of dermal melanocytosis?

In all forms of dermal melanocytosis:

  • Colour may vary to include brown-violet, violet-blue or blue-green hues
  • Naevi present in childhood may slowly grow and darken until adulthood is reached
  • Colour or perceived colour of naevi may change according to personal and environmental conditions, e.g. fatigue, menstruation, hot weather
  • If affecting the eye, melanocytosis rarely causes glaucoma
  • Melanoma very rarely develops within dermal melanocytosis, and has usually been reported in Caucasians. Ocular melanoma has rarely been reported in the choroid, brain, orbit, iris, ciliary body, and optic nerve in association with a nevus of Ota.

How is the diagnosis of dermal melanocytosis made?

The diagnosis of dermal melanocytosis is usually made by observing typical discolouration of the skin. It is classified according to the site affected.

Some patients may undergo skin biopsy, which confirms the presence of melanocytes in the dermis.

Other skin conditions resulting in bluish or grey coloured skin may be considered. These include:

What treatments are available for melanocytosis?

Treatment of a melanocytosis may include cosmetic camouflage to cover the disfiguring markings, and laser treatment (usually using 1064nm Q switched Nd:YAG, Alexandrite or QS ruby laser) or intense pulsed light (IPL).

  • Picosecond laser may be the most effective device.
  • Laser and light devices work by destroying the dermal melanocytes.
  • Multiple treatments are necessary, often with a combination of devices.
  • Laser treatment is more effective in treating melanocytosis in light skinned individuals compared to those with dark skin.
  • Recurrence is common after laser clearance, sometimes resulting in a darker hue than prior to treatment.

If the eye is affected, regular eye examinations should be arranged to detect glaucoma. Any change in a naevus should be assessed by a dermatologist.



  • Book: Textbook of Dermatology. Ed Rook A, Wilkinson DS, Ebling FJB, Champion RH, Burton JL. Blackwell Scientific Publications.

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