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Author: A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand, 1997. Updated in July 2016. DermNet NZ Revision September 2021
Tetracyclines are a family of related oral antibiotics often used to treat skin diseases. There has been over 50 years' experience with these medications, which were originally derived from the soil bacterium Streptomyces aureofaciens.
The original base medicines, chlortetracycline, tetracycline, and oxytetracycline, have been replaced by products that are better absorbed and more lipophilic, with excellent tissue distribution. These include:
Doxycycline is the most commonly prescribed tetracycline.
Chemically modified tetracyclines are under development to reduce antibiotic activity and to increase their non-antibiotic, anti-inflammatory effect.
Tetracyclines are broad spectrum antibiotics often used to treat skin, chest, urethral, and pelvic infections. Doxycycline is indicated in a wide range of infections including syphilis, Lyme disease, Q fever, Rocky Mountain spotted fever, and plague. It is also widely used for malaria prophylaxis.
Doxycycline is also effective at controlling non-infectious, inflammatory skin and mucosal diseases, including:
As antibiotics, tetracyclines interfere with protein synthesis of susceptible bacteria.
They are also anti-inflammatory agents.
The antibiotic dose of doxycycline is 100 mg once or twice daily. It should be taken while upright, with plenty of water.
Lower doses of doxycycline have been shown to be effective in rosacea (20 mg twice daily or 40 mg once daily). The lowest dose of doxycycline available in New Zealand is 50 mg. The effect of low-dose doxycycline in other skin disorders is unknown and it is quite common for an antibiotic dose to be prescribed.
A topical foam formulation of minocycline was approved for use in acne by the Food and Drug Administration in the US in 2019.
Infections are treated for 7 to 28 days, depending on the condition.
Inflammatory disorders take several weeks or months to respond to tetracyclines such as doxycycline. They are often prescribed for months or years for inflammatory skin disorders. They are not curative for these conditions.
There is a lag period of one to three weeks between the change in dosage and its effect on the skin. If the skin problem becomes worse following a dose reduction, return to the previous higher dosage and continue on it or as advised by your doctor.
Tetracyclines must not be taken by pregnant or breastfeeding women, or by children under 12 years, because they discolour growing teeth and may cause enamel hypoplasia (malformed permanent teeth). Staining of permanent teeth is usually temporary but can persist for lifelong. Staining can also affect bones.
Doxycycline is usually tolerated very well, particularly in a subantibiotic dose. Allergy can occur, but it’s rare. There are some important precautions.
Minocycline has an increased risk of severe adverse effects compared to doxycycline, so it best to avoid minocycline as a first-line agent. These include:
Minocycline is less likely than doxycycline to cause photosensitivity.
Important drug interactions of tetracycline and its derivatives include:
There is little evidence that tetracyclines reduce the efficacy of the oral contraceptive pill unless they cause gastrointestinal upset. However, to be absolutely safe, extra precautions should be taken, particularly in the first four weeks of starting the antibiotics. Discuss this with your doctor.
If you develop side effects, advise your doctor. You may need to stop taking the tetracycline or change brand.
If you are not based in New Zealand, we suggest you refer to your national drug approval agency for further information about medicines (eg, the Australian Therapeutic Goods Administration and the US Food and Drug Administration) or a national or state-approved formulary (eg, the New Zealand Formulary and New Zealand Formulary for Children and the British National Formulary and British National Formulary for Children).
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