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Cherry angioma

Author: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand, December 2017. Revised September 2020


Cherry angioma — codes and concepts
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What is an angioma?

Angioma or haemangioma (American spelling ‘hemangioma’) describes a benign vascular skin lesion. An angioma is due to proliferating endothelial cells; these are the cells that line the inside of a blood vessel.

Angiomas can arise in early life (infantile proliferative haemangioma) or later in life; the most common type of angioma is a cherry angioma.

What is a cherry angioma?

A cherry angioma is a small papular angioma. It is a true capillary haemangioma. Cherry angioma has many synonyms, the most commonly used being Campbell de Morgan spots.

Cherry angiomas

See more images of cherry angioma.

Who gets cherry angioma?

Cherry angiomas markedly increase in number from about the age of 40, so it has been estimated that 75% of people over 75 years of age have them. Although they also called senile angiomas, they can occur in young people too - 5% of adolescents have been found to have them. Cherry angiomas are very common in males and females of any age or race, with no difference in sexes or races affected. They are however more noticeable in white skin than in skin of colour.  There may be a family history of similar lesions. Eruptive cherry angiomas have been rarely reported to be associated with internal malignancy and pregnancy.

What is the cause of cherry angioma?

The cause of cherry angiomas is unknown. Genetic analysis has found cherry angiomas frequently carry specific somatic missense mutations in the GNAQ and GNA11 (Q209H) genes, which are also involved in other vascular and melanocytic proliferations.

What are the clinical features of cherry angioma?

Cherry angioma is an asymptomatic firm red, blue, or purple papule, 0.1–1 cm in diameter. When thrombosed, it can appear black in colour until examined with a dermatoscope when the red or purple colour is more easily seen. Cherry angiomas are usually multiple. They are usually scattered over any part of the body surface, but are rarely found on the hands and feet or mucous membranes. 

What is the differential diagnosis for cherry angioma?

Cherry angioma is usually easy to diagnose, but occasionally it may be confused with:

Spider telangiectasis, also known as spider naevus, is sometimes (incorrectly) called a spider angioma but this is a vascular dilatation and not a proliferation of endothelial cells. 

What investigations should be done for cherry angioma?

Cherry angioma is usually diagnosed clinically and investigation is not necessary for the majority of lesions. It has a characteristic red-clod or lobular pattern on dermoscopy (called lacunar pattern using conventional pattern analysis).

When there is uncertainty about the diagnosis, a biopsy may be performed. The angioma is composed of venules in a thickened papillary dermis. Collagen bundles may be prominent between the lobules. See cherry angioma pathology.

What is the treatment for cherry angioma?

Cherry angiomas are harmless, so do not have to be treated. Occasionally, they are removed to exclude a malignant skin lesion such as nodular melanoma.

Cherry angioma excised to exclude melanoma

If desired for cosmetic reasons, a cherry angioma can be simply removed by one of the following methods:

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References

  • Klebanov N, Lin WM, Artomov M, et al. Use of targeted next-generation sequencing to identify activating hot spot mutations in cherry angiomas. JAMA Dermatol. 2019;155(2):211-15. doi:10.1001/jamadermatol.2018.4231. Journal.
  • Corazza M, Dika E, Maietti E, Musmeci D, Patrizi A, Borghi A. Eruptive cherry angiomas and skin melanoma: a fortuitous association?. Melanoma Res. 2019;29(3):313-17. doi:10.1097/CMR.0000000000000563. PubMed
  • Valdebran M, Martin B, Kelly KM. State-of-the-art lasers and light treatments for vascular lesions: from red faces to vascular malformations. Semin Cutan Med Surg. 2017;36(4):207-12. doi:10.12788/j.sder.2017.044. PubMed
  • Goldsmith PC. Dermatoses resulting from disorders of the veins and arteries. In:Griffiths C, Barker J, Bleiker T, Chalmers R, Creamer D (eds). Rook's Textbook of Dermatology [4 volumes], 9th edn, Wiley Blackwell, 2016: 103.12-13.

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