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Author: Vanessa Ngan, Staff Writer, 2003. Updated by A/Prof Amanda Oakley, February 2016.


What is erythroderma?

Erythroderma is the term used to describe intense and usually widespread reddening of the skin due to inflammatory skin disease. It often precedes or is associated with exfoliation (skin peeling off in scales or layers), when it may also be known as exfoliative dermatitis (ED).


See more images of erythroderma.

Who gets erythroderma and what is the cause?

Erythroderma is rare. It can arise at any age and in people of all races. It is about 3 times more common in males than in females. Most have a pre-existing skin disease or a systemic condition known to be associated with erythroderma. About 30% of cases of erythroderma are idiopathic.

Erythrodermic atopic dermatitis most often affects children and young adults, but other forms of erythroderma are more common in middle-aged and elderly people.

The most common skin conditions to cause erythroderma are:

Other skin diseases that less frequently cause erythroderma may include:

Erythroderma may also be a symptom or sign of systemic disease. These may include:

It is not known why some skin diseases in some people progress to erythroderma. The pathogenesis is complicated, involving keratinocytes and lymphocytes, and their interaction with adhesion molecules and cytokines. The result is a dramatic increase in turnover of epidermal cells.

What are the clinical features of erythroderma?

Erythroderma is often preceded by a morbilliform (measles-like) eruption, dermatitis, or plaque psoriasis. Generalised erythema can develop quite rapidly in acute erythroderma, or more gradually over weeks to months in chronic erythroderma.

Signs and symptoms of erythroderma

By definition, generalised erythema and oedema or papulation affect 90% or more of the skin surface.

  • The skin feels warm to the touch.
  • Itch is usually troublesome and is sometimes intolerable. Rubbing and scratching leads to lichenification.
  • Eyelid swelling may result in ectropion.
  • Scaling begins 2-6 days after the onset of erythema, as fine flakes or large sheets.
  • Thick scaling may develop on the scalp with varying degrees of hair loss including complete baldness.
  • Palms and soles may develop yellowish, diffuse keratoderma.
  • Nails become dull, ridged, and thickened or develop onycholysis and may shed (onychomadesis).
  • Lymph nodes become swollen (generalised dermatopathic lymphadenopathy).

Clues may be present as to the underlying cause.

  • Serous ooze, resulting in clothes and dressings sticking to the skin and an unpleasant smell, is characteristic of atopic erythroderma.
  • Persistence of circumscribed scaly plaques in certain sites such as elbows and knees suggests psoriasis.
  • Islands of sparing, follicular prominence, orange-hue to keratoderma are typical of pityriasis rubra pilaris.
  • Subungual hyperkeratosis, crusting on palms and soles, and burrows are indicative of crusted scabies.
  • Sparing of abdominal creases (deck chair sign) is typical of papuloerythroderma of Ofuji.

Systemic symptoms may be due to the erythroderma or to its cause.

  • Lymphadenopathy, hepatosplenomegaly, abnormal liver dysfunction and fever may suggest a drug hypersensitivity syndrome or malignancy.
  • Leg oedema may be due to inflamed skin, high output cardiac failure and/or hypoalbuminaemia.

Complications of erythroderma

Erythroderma often results in acute and chronic local and systemic complications. The patient is unwell with temperature dysregulation and losing a great deal of fluid by transpiration through the skin.

  • Heat loss leads to hypothermia.
  • Fluid loss leads to electrolyte abnormalities and dehydration.
  • Red skin leads to high-output heart failure.
  • A secondary skin infection may occur (impetigo, cellulitis).
  • General unwellness can lead to pneumonia.
  • Hypoalbuminaemia from protein loss and increased metabolic rate causes oedema.
  • Longstanding erythroderma may result in pigmentary changes (brown and/or white skin patches).

How is erythroderma diagnosed?

The blood count may show anaemia, white cell count abnormalities, and eosinophilia. Marked eosinophilia should raise suspicions for lymphoma.

  • > 20% circulating Sézary cells suggests Sézary syndrome
  • C-reactive protein may or may not be elevated.
  • Proteins may reveal hypoalbuminaemia and abnormal liver function.
  • Polyclonal gamma globulins are common, and raised immunoglobulin E (IgE) is typical of idiopathic erythroderma.

Skin biopsies from several sites may be taken if the cause is unknown. They tend to show nonspecific inflammation on histopathology. Diagnostic features may also be present.

Direct immunofluorescence is of benefit if an autoimmune blistering disease or connective tissue disease is considered.

What is the treatment for erythroderma?

Erythroderma is potentially serious, even life-threatening, and the patient may require hospitalisation for monitoring and to restore fluid and electrolyte balance, circulatory status, and body temperature.

The following general measures apply:

If a cause can be identified then specific treatment should be started, such as topical and systemic steroids for atopic dermatitis; acitretin or methotrexate for psoriasis.

How can erythroderma be prevented?

In most cases, erythroderma cannot be prevented.

People with known drug allergy should be made aware that they should avoid the drug forever, and if their reaction was severe, wear a drug alert bracelet. All medical records should be updated if there is an adverse reaction to a medication and referred to whenever starting a new drug.

Patients with severe skin diseases should be informed if they are at known risk of erythroderma. They should be educated about the risks of recurrence should they discontinue their medication.

What is the outlook for erythroderma?

Prognosis of erythroderma depends on the underlying disease process. If the cause can be removed or corrected, the prognosis is generally good.

If erythroderma is the result of a generalised spread of a primary skin disorder such as psoriasis or dermatitis, it usually clears with appropriate treatment of the skin disease but may recur at any time.

The course of idiopathic erythroderma is unpredictable. It may persist for a long time with periods of acute exacerbation.



  • Textbook of Dermatology. Ed Rook A, Wilkinson DS, Ebling FJB, Champion RH, Burton JL. Fourth edition. Blackwell Scientific Publications.
  • Okoduwa C, Lambert WC, Schwartz RA, et al. Erythroderma: review of a potentially life-threatening dermatosis. Indian Journal of Dermatology. 2009;54(1):1–6. doi:10.4103/0019-5154.48976. PubMed Central

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