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Authors: Created 1997; Updated: Dr Sashika Samaranayaka, Post Graduate Year 1, Department of Dermatology, Middlemore Hospital, Auckland, New Zealand; Hon Assoc Prof Paul Jarrett, Dermatologist, Clinical Head Dermatology, Middlemore Hospital and Department of Medicine, The University of Auckland, Auckland, New Zealand. Copy edited by Gus Mitchell. July 2021
Topical retinoids are medications derived from vitamin A formulated as a cream, lotion, foam, emulsion, or gel.
Applied to the face once daily at bedtime, topical retinoids such as adapalene, isotretinoin, tretinoin (retinoic acid), and trifarotene can help mild to moderately severe acne. They are effective first-line treatment for comedonal and inflammatory acne, but are not recommended as monotherapy for severe acne, especially if there are pustules with deep nodules and cysts. It may take 12 weeks or longer before improvement is seen.
Topical retinoids may reduce the severity of existing scarring and subsequent acne scarring.
Inflammatory dermatoses including acne vulgaris may resolve with postinflammatory hyperpigmentation particularly in skin of colour. Topical retinoids are useful to treat post-inflammatory hyperpigmentation as they inhibit melanosome transfer and facilitate melanin dispersal. They are particularly recommended for the treatment of acne in skin of colour.
Topical retinoids can be used to treat facial acne
Topical isotretinoin, tretinoin, and adapelene have been used for localised Darier disease, reporting significant clinical improvement in symptoms. Topical retinoids may be used to treat many dermatoses - see the list of page links below (On DermNet NZ).
Skin conditions that may be treated with topical retinoids
Dryness due to a topical retinoid
Retinoids act at a cellular level. They activate genes involved in the physiology of keratinocytes by binding to specific nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR).
Topical retinoids such as retinol and retinaldehyde are commonly added to cosmetics.
Prescribed topical retinoids include adapalene, alitretinoin, tazarotene, tretinoin, and trifarotene. They come in a variety of formulations. Gels are the least cosmetically noticeable; creams are the least irritating. Applying them at night (or just before sleep) mean they are less noticeable when treating the face. The regular application of a sunblock/moisturiser combination during the day will protect against the sun sensitivity and dryness.
Retinoids can be classified as:
If you are not based in New Zealand, we suggest you refer to your national drug approval agency for further information about medicines (eg, the Australian Therapeutic Goods Administration and the US Food and Drug Administration) or a national or state-approved formulary (eg, the New Zealand Formulary and New Zealand Formulary for Children and the British National Formulary and British National Formulary for Children).
Books about skin diseases
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DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice.